王亮教授

    王亮教授,山东省日照市人,有机化学博士,硕士研究生导师。

    博士毕业于德国海德堡大学(德国精英大学) ,现为有机分子智造团队的带头人。

    电子信箱: liangwang0532@yeah.net 

   教育和工作经历

  2014-至今,betway必威西汉姆联官网,必威,教授                           

  2012-2013,瑞士巴塞尔大学,博士后,合作导师:Andreas Pfaltz    

   2008-2011,海德堡大学,有机化学,博士,导师:Dirk Menche       

2003-2006,西南大学,有机化学,硕士                                          

  1998毕业于山东大学化学化工学院                                                  

 

主持的科研项目

1.国家自然科学基金面上项目,21776148,活性氮杂环骨架的高效构建及药物合成研究,2018/01-2021/1264 万,主持  

2.山东省自然科学基金面上项目,ZR2016BM07,新型串联不对称氢迁移环化反应研究,2016/11-2019/0614万元,主持

3. 2018年山东省重点研发计划, 2018GSF118224 基于海洋天然产物pestaloxazine A的抗病毒药物开发, 2018/01-2019/1210 万,主持

4. 青岛市科技惠民专项医疗卫生项目,16-6-2-29-nsh,合成杂环药物的新方法研究,2016/09-2018/0910万元,主持

5. 药物合成与优化湖北省重点实验室开放基金重点项目,OPP2015ZD02,串联不对称C(sp3)-H键活化构建杂环化合物,2015/09-2017/094万元,主持

6.betway必威西汉姆联官网高层次人才启动基金,6631115015,杂环化合物新合成方法研究,2015/12-2019/1130万,主持

 发表的科研论文

第一作者及通讯作者论文

(1) Ye Liu, Yujian Mao, Yanwei Hu, Jingjing Gui, Liang Wang,* Wei Wang, Shilei Zhang*, The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds, Adv. Syn. Catal. 2019, DOI: 10.1002/adsc.201801676

 (2) Didi Ren, Lubin Xu, Liang Wang*, Shuai-Shuai Li*, Catalytic Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents, Org. Lett. 2019, 21, 627.

 (3) Manli Yang, Liang Wang*, Yanzhi Xia*, Ammonium persulphate induced synthesis of polymethyl methacrylate grafted sodium alginate composite films with high strength for food packaging, Int. J. Bio. Macro. 2019, 124, 1238.

(4) Mingyan XiaoShuai ZhuYaobin ShenLiang Wang*, Jian Xiao*, Construction of Chiral Cyclic Compounds via Asymmetric Cascade [1,n]-Hydride Transfer/Cyclization, Chin. J. Org. Chem. 2018, 38(2): 328-340,

(5) Chunqi Chen, Lubin Xu, Liang Wang* and Shuai-Shuai Li*, Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization, Org. Biomol. Chem. 2018, 16, 7109–7114.

(6) Lubin Xu, Pengfei Yang, Liang Wang*, Direct functionalization of benzylic and nonbenzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization, Org. Chem. Front., 2018, 5, 1854–1858.

(7) Shuai Zhu, Chunqi Chen, Mingyan Xiao, Liping Yu, Liang Wang*, Jian Xiao*, Construction of the Tetrahydroquinoline Spiro Skeleton via Cascade [1,5]-Hydride Transfer-involved C(sp3)-H Functionalization “on Water”, Green Chem., 2017, 19(23): 5653.

(8) Huaili ZhaoMingyan XiaoLubin XuLiang Wang* Jian XiaoBifunctional thiourea catalyzed asymmetric Michael addition of anthrone to methyleneindolinonesRSC Adv., 2016, 6(45): 38558~38562

(9) Huaili ZhaoXiaoxiao WangLiang Wang* Jian XiaoRegioselective Michael Addition of Anthrone to Methyleneindolinones, Synthesis, 2016, 48(13): 2112~2120

(10) Jian Liu, Xiaoxiao Wang, Lubin Xu, Zhihui Hao, Liang Wang*, Jian Xiao *, One step synthesis of 2-alkenylchromanes via inverse-electron-demand Hetero-DielseAlder reaction of o-quinone methide with unactivated dienes, Tetrahedron 2016, 72, 7642-7649.

(11) Liang Wang, Jian Xiao, Hydrogen-Atom Transfer Reactions, Top. Curr. Chem. 2016, 374, 17.

(12)  Shuai Zhu, Lubin Xu, Liang Wang*, Jian Xiao*, Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols, Chin. J. Org. Chem. 2016, 36(6): 1229-1240.

(13) Liang WangJian XiaoC(sp3)–H bond functionalization by sequential hydride transfer/cyclization: Electronic effect and steric effect controlled regioselectivity, Org. Chem. Front.20163(5): 635~638

(14) Xiaoxiao Wang, Jian Liu, Lubin Xu, Zhihui Hao, Liang Wang* and Jian Xiao*, Friedel–Crafts alkylation of heteroarenes and arenes with indolyl alcohols for construction of 3,3-disubstituted oxindoles, RSC Adv., 2015, 5, 101713–101717.

(15) Liang Wang, Jian Xiao, Advancement in Cascade [1,n]-Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)-H BondsAdv. Syn. Catal., 2014, 356(6): 1137~1171

(16) Liang WangYuye Chen, Jian XiaoAlkylideneindoleninium Ions and Alkylideneindolenines: Key Intermediates for the Asymmetric Synthesis of 3-Indolyl DerivativesAsian J. Org. Chem., 2014, 3(10): 1036~1052

(17) Liang Wang, Jian Xiao, Teck-Peng Loh, Organocatalytic β-Functionalization of Saturated Carbonyl Compounds-the State of the Art, ChemCatChem, 2014, 6(5): 1183~1185.

(18) Liang WangDirk MencheConcise synthesis of acetal-protected syn 1,3-diols by a tandem hemiacetal/ formation/Tsuji-Trost reaction, Angew. Chem. Int. Ed. 2012, 51(37): 9425~9427

(19) Liang WangDirk MenchConstruction of multisubstituted tetrahydropyrans by a domino oxa-Michael/Tsuji-Trost reactionJ. Org. Chem. 2012, 77(23): 10811~10823

(20) Liang Wang, Pengfei Li, Dirk Menche, Concise synthesis of tetrahydropyrans by a tandem oxa-Michael/Tsuji-Trost reaction.Angew. Chem. Int. Ed. 2010, 49(48): 9270~9273.

 

 非第一作者及通讯作者论文

(1) Bin TangLiang Wang, Dirk MencheDiastereoselective Synthesis of 1,3-syn-Oxazines via a Tandem Hemiaminalization/Tsuji-Trost Reaction, Synlett, 2013, 0(24): 625~629

(2) Zhuzhou ShaoLubin XuLiang WangHongtao WeiJian XiaoCatalyst-free tandem Michael addition/decarboxylation of (thio)coumarin-3- carboxylic acids with indoles: facile synthesis of indole-3-substituted 3,4-dihydro(thio)coumarinsOrg. Biomol. Chem., 2014, 12(14): 2185~2188

(3) Lubin Xu, Zhuzhou ShaoLiang WangJian XiaoTandem sp3 C-H functionlization/decarboxylation of 2-alkylazaarenes with coumarin-3-carboxylic acids.Org. Lett., 2014, 16(3): 796~799

(4) Lubin XuZhuzhou ShaoLiang WangHuaili ZhaoJian XiaoCatalyst-free synthesis of (E)-2-alkenylquinoline derivatives via C(sp3)-H functionalization of 2-methylquinolinesTetrahedron Lett., 2014, 55(50):  6856~6860

(5) Zhuzhou ShaoLiang WangLubin XuHuaili ZhaoJian XiaoFacile synthesis of azaarene-2-substituted chromanone derivatives via tandem sp3 C–H functionalization/decarboxylation of azaarenes with 4-oxo-4H-chromene-3-carboxylic acidRSC Adv., 2014, 4(95): 53188~53191

(6) Jian Xiao, Yuye Chen, Shuai Zhu, Lubin XuHongtao Wei, Liang Wang, Diversified Construction of Chromeno[3,4-c]pyridin-5-one and Benzo[c]chromen- 6-one Derivatives by Domino Reaction of 4-alkynyl-2-oxo-2H-chromene- 3-carbaldehydesAdv. Synth. Catal. 2014, 356(8): 1835~1845

(7) Zhuzhou ShaoLiang WangLubin XuHuaili ZhaoJian XiaoFacile synthesis of azaarene-2-substituted chromanone derivatives via tandem sp3 C–H functionalization/decarboxylation of azaarenes with 4-oxo-4H-chromene-3- carboxylic acidRSC Adv., 2014, 4(95): 53188~53191

( 8) Hao WenLiang WangLubin XuZhihui HaoChang-Lun ShaoChang-Yun WangJian XiaoFluorinated Alcohol-Mediated SN1-Type Reaction of Indolyl Alcohols with Diverse NucleophilesAdv. Synth. Catal., 2015357(18): 4023~4030

(9) Jian XiaoHao WenLiang WangLubin XuZhihui HaoChang-Lun ShaoChang-Yun WangCatalyst-free dehydrative SN1-type reaction of indolyl alcohols with diverse nucleophiles “on water”, Green Chemistry, 2015, 18(4): 1032~1037

(10) Jian LiuLiang WangXiaoxiao WangLubin XuZhihui HaoJian Xiao, Fluorinated alcohol-mediated [4 + 3] cycloaddition reaction of indolyl alcohols with cyclopentadieneOrg. Biomol. Chem., 2016, 14(48): 11510~11517

(11) Shiheng FuLiang WangHaoxun DongJunqiang YuLubin XuJian XiaoFacile synthesis of 2-alkenylazaarenes via dehydrative coupling of 2-methylazaarenes with aldehydes ‘on water’, Tetrahedron Lett., 2016, 57(41): 4533~4536

(12) Xianhui ZhangShuai-Shuai LiLiang WangLubin XuJian XiaoZhen-Jiang Liu2-Methylquinoline promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO: facile synthesis of α-amino aryl ketonesTetrahedron, 2016, 72(49): 8073~8077

(13) Haoxun DongLubin XuShuai-Shuai LiLiang WangChang-Lun ShaoJian XiaoFacile Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp(3))-H Functionalization, ACS Combinatorial Science, 2016, 18(9): 604~610

(14) Xianhui Zhang, Shuai-Shuai Li, Liang Wang, Lubin Xu, Jian Xiao*, 2-Methylquinoline promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO: facile synthesis of a-amino aryl ketones, Tetrahedron 2016, 72(49): 8073-8077.

 (15) Shuai-Shuai Li, Shiheng Fu, Liang Wang, Lubin Xu, and Jian Xiao, t‑BuOK-Mediated Oxidative Dehydrogenative C(sp3)‑H Arylation of 2‑Alkylazaarenes with Nitroarenes, J. Org. Chem. 2017, 82(16): 8703−8709

(15) Shuai-Shuai Li, Lan Zhou, Liang Wang, Huaili Zhao, Liping Yu, and Jian Xiao, Organocatalytic C(sp3)−H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]-azepines, Org. Lett. 2018, 20(1): 138−141

(16) Shuai-Shuai Li, Lan Zhou, Liang Wang, Huaili Zhao, Liping Yu, and Jian Xiao*, Organocatalytic C(sp3)−H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo- [b,e]azepines, Org. Lett. 2018, 20, 138−141.

(17) Wei Cao, Ping Chen, Liang Wang, Hao Wen, Yu Liu, Wanshu Wang and Yu Tang*, A Highly Regio- and Stereoselective Syntheses of α‑Halo Enamides, Vinyl Thioethers, and Vinyl Ethers with Aqueous Hydrogen Halide in Two-Phase Systems, Org. Lett. 2018, 20, 4507−4511.

(18) Yujian Mao, Ye Liu, Yanwei Hu, Liang Wang, Shilei Zhang* and Wei Wang*, Pd-Catalyzed Debenzylation and Deallylation of Ethers and Esters with Sodium Hydride, ACS Catal. 2018, 8, 3016−3020.

(19) Hao Wen, Wei Cao, Yu Liu, Liang Wang, Ping Chen*, Yu Tang*, Metal-Free [2 + 2 + 2] Cycloaddition of Ynamide−Nitriles with Ynamides: A Highly Regio- and Chemoselective Synthesis of δ‑Carboline Derivatives, J. Org. Chem. 2018, 83, 13308−13324.

(20) Yao-Bin Shen, Shuai-Shuai Li, Liang Wang, Xiao-De An, Qing Liu, Xicheng Liu, and Jian Xiao, Organocatalytic Dearomative [4 + 2] Cycloadditions of Biomass-Derived 2,5-Dimethylfuran with ortho-Quinone Methides: Access to Multisubstituted Chromanes, Org. Lett. 2018, 20, 6069−6073.