王亮教授
王亮教授,山东省日照市人,有机化学博士,硕士研究生导师。
博士毕业于德国海德堡大学(德国精英大学) ,现为有机分子智造团队的带头人。
电子信箱: liangwang0532@yeah.net
教育和工作经历
2014-至今,betway必威西汉姆联官网,必威,教授
2012-2013,瑞士巴塞尔大学,博士后,合作导师:Andreas Pfaltz
2008-2011,海德堡大学,有机化学,博士,导师:Dirk Menche
2003-2006,西南大学,有机化学,硕士
1998毕业于山东大学化学化工学院
主持的科研项目
1.国家自然科学基金面上项目,21776148,活性氮杂环骨架的高效构建及药物合成研究,2018/01-2021/12,64 万,主持
2.山东省自然科学基金面上项目,ZR2016BM07,新型串联不对称氢迁移环化反应研究,2016/11-2019/06,14万元,主持
3. 2018年山东省重点研发计划, 2018GSF118224, 基于海洋天然产物pestaloxazine A的抗病毒药物开发, 2018/01-2019/12,10 万,主持
4. 青岛市科技惠民专项医疗卫生项目,16-6-2-29-nsh,合成杂环药物的新方法研究,2016/09-2018/09,10万元,主持
5.
药物合成与优化湖北省重点实验室开放基金重点项目,OPP2015ZD02,串联不对称C(sp3)-H键活化构建杂环化合物,2015/09-2017/09,4万元,主持
6.betway必威西汉姆联官网高层次人才启动基金,6631115015,杂环化合物新合成方法研究,2015/12-2019/11,30万,主持
第一作者及通讯作者论文
(1) Ye Liu, Yujian Mao, Yanwei Hu, Jingjing
Gui, Liang Wang,* Wei
Wang, Shilei Zhang*, The Employment of Sodium Hydride as a Michael
Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl
Compounds, Adv. Syn. Catal.
2019, DOI: 10.1002/adsc.201801676
(2)
Didi Ren, Lubin Xu, Liang Wang*, Shuai-Shuai Li*, Catalytic
Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran
Derivatives with Ferrocenyl Alcohols as Alkylation Reagents,
Org. Lett. 2019, 21, 627.
(3)
Manli Yang, Liang Wang*, Yanzhi Xia*, Ammonium persulphate
induced synthesis of polymethyl methacrylate grafted sodium alginate
composite films with high strength for food packaging,
Int. J. Bio. Macro. 2019,
124, 1238.
(4)
Mingyan Xiao,Shuai Zhu,Yaobin Shen,Liang Wang*, Jian Xiao*,
Construction of Chiral Cyclic Compounds via Asymmetric Cascade
[1,n]-Hydride Transfer/Cyclization,
Chin. J. Org. Chem.
2018, 38(2): 328-340,
(5) Chunqi Chen, Lubin Xu,
Liang Wang* and
Shuai-Shuai Li*, Efficient construction of tetrahydroquinolines via
fluorinated alcohol mediated cascade [1,5]-hydride
transfer/cyclization, Org.
Biomol. Chem. 2018,
16, 7109–7114.
(6) Lubin Xu, Pengfei Yang, Liang Wang*,
Direct functionalization of benzylic and nonbenzylic C(sp3)–H bonds
via keteniminium ion initiated cascade [1,5]-hydrogen
transfer/cyclization, Org. Chem. Front., 2018, 5, 1854–1858.
(7) Shuai Zhu, Chunqi Chen, Mingyan Xiao,
Liping Yu, Liang Wang*,
Jian Xiao*, Construction of the Tetrahydroquinoline Spiro Skeleton
via Cascade [1,5]-Hydride Transfer-involved C(sp3)-H
Functionalization “on Water”,
Green Chem., 2017, 19(23): 5653.
(8) Huaili Zhao,Mingyan Xiao,Lubin Xu,Liang Wang*, Jian Xiao,Bifunctional thiourea catalyzed asymmetric Michael
addition of anthrone to methyleneindolinones,RSC Adv., 2016, 6(45): 38558~38562
(9) Huaili Zhao,Xiaoxiao Wang,Liang Wang*, Jian Xiao,Regioselective Michael Addition of Anthrone to
Methyleneindolinones, Synthesis, 2016, 48(13): 2112~2120
(10) Jian Liu, Xiaoxiao Wang, Lubin Xu,
Zhihui Hao, Liang Wang*,
Jian Xiao *, One step synthesis of 2-alkenylchromanes via
inverse-electron-demand Hetero-DielseAlder reaction of o-quinone
methide with unactivated dienes,
Tetrahedron
2016,
72, 7642-7649.
(11) Liang Wang, Jian Xiao,
Hydrogen-Atom Transfer Reactions,
Top. Curr. Chem.
2016, 374, 17.
(12)
Shuai
Zhu, Lubin Xu, Liang Wang*, Jian Xiao*, Recent Advances in
Asymmetric Synthesis of Optically Active Indole Derivatives from
3-Indolylmethanols, Chin. J. Org. Chem. 2016, 36(6):
1229-1240.
(13)
Liang Wang,Jian Xiao,C(sp3)–H bond functionalization by sequential hydride
transfer/cyclization: Electronic effect and steric effect controlled
regioselectivity, Org. Chem.
Front.,2016,3(5): 635~638
(14) Xiaoxiao Wang, Jian Liu, Lubin Xu,
Zhihui Hao, Liang Wang* and Jian Xiao*, Friedel–Crafts alkylation of
heteroarenes and arenes with indolyl alcohols for construction of
3,3-disubstituted oxindoles,
RSC Adv., 2015, 5, 101713–101717.
(15)
Liang Wang, Jian Xiao, Advancement in Cascade [1,n]-Hydrogen
Transfer/Cyclization: A Method for Direct Functionalization of
Inactive C(sp3)-H Bonds,Adv. Syn. Catal., 2014, 356(6): 1137~1171
(16)
Liang Wang,Yuye Chen, Jian Xiao,Alkylideneindoleninium Ions and
Alkylideneindolenines: Key Intermediates for the Asymmetric
Synthesis of 3-Indolyl Derivatives,Asian J. Org. Chem., 2014, 3(10): 1036~1052
(17)
Liang Wang, Jian Xiao, Teck-Peng Loh, Organocatalytic
β-Functionalization of Saturated Carbonyl Compounds-the State of the
Art, ChemCatChem, 2014, 6(5): 1183~1185.
(18)
Liang Wang,Dirk Menche,Concise synthesis of acetal-protected syn 1,3-diols by a
tandem hemiacetal/ formation/Tsuji-Trost reaction, Angew. Chem.
Int. Ed. 2012, 51(37): 9425~9427
(19)
Liang Wang,Dirk Mench,Construction of multisubstituted tetrahydropyrans by a
domino oxa-Michael/Tsuji-Trost reaction,J. Org. Chem.
2012,
77(23): 10811~10823
(20) Liang Wang, Pengfei Li, Dirk Menche, Concise synthesis of tetrahydropyrans by a tandem oxa-Michael/Tsuji-Trost reaction.,Angew. Chem. Int. Ed. 2010, 49(48): 9270~9273.
(1) Bin Tang,Liang
Wang,
Dirk Menche,Diastereoselective
Synthesis of 1,3-syn-Oxazines via a Tandem
Hemiaminalization/Tsuji-Trost Reaction, Synlett, 2013, 0(24):
625~629
(2) Zhuzhou Shao,Lubin
Xu,Liang
Wang,Hongtao
Wei,Jian
Xiao,Catalyst-free
tandem Michael addition/decarboxylation of (thio)coumarin-3-
carboxylic acids with indoles: facile synthesis of
indole-3-substituted 3,4-dihydro(thio)coumarins,Org.
Biomol. Chem.,
2014, 12(14): 2185~2188
(3) Lubin Xu, Zhuzhou Shao,Liang
Wang,Jian
Xiao,Tandem
sp3 C-H functionlization/decarboxylation of 2-alkylazaarenes with
coumarin-3-carboxylic acids.,Org.
Lett.,
2014, 16(3): 796~799
(4) Lubin Xu,Zhuzhou
Shao,Liang
Wang,Huaili
Zhao,Jian
Xiao,Catalyst-free
synthesis of (E)-2-alkenylquinoline derivatives via C(sp3)-H
functionalization of 2-methylquinolines,Tetrahedron
Lett.,
2014, 55(50): 6856~6860
(5) Zhuzhou Shao,Liang
Wang,Lubin
Xu,Huaili
Zhao,Jian
Xiao,Facile
synthesis of azaarene-2-substituted chromanone derivatives via
tandem sp3 C–H functionalization/decarboxylation of azaarenes with
4-oxo-4H-chromene-3-carboxylic acid,RSC
Adv.,
2014, 4(95): 53188~53191
(6) Jian Xiao, Yuye Chen, Shuai Zhu, Lubin Xu,Hongtao
Wei, Liang Wang,
Diversified Construction of Chromeno[3,4-c]pyridin-5-one and
Benzo[c]chromen- 6-one Derivatives by Domino Reaction of
4-alkynyl-2-oxo-2H-chromene- 3-carbaldehydes,Adv.
Synth. Catal.
2014, 356(8): 1835~1845
(7) Zhuzhou Shao,Liang
Wang,Lubin
Xu,Huaili
Zhao,Jian
Xiao,Facile
synthesis of azaarene-2-substituted chromanone derivatives via
tandem sp3 C–H functionalization/decarboxylation of azaarenes with
4-oxo-4H-chromene-3- carboxylic acid,RSC
Adv.,
2014, 4(95): 53188~53191
( 8) Hao Wen,Liang
Wang,Lubin
Xu,Zhihui
Hao,Chang-Lun
Shao,Chang-Yun
Wang,Jian
Xiao,Fluorinated
Alcohol-Mediated SN1-Type Reaction of Indolyl Alcohols with Diverse
Nucleophiles,Adv.
Synth. Catal.,
2015,357(18):
4023~4030
(9) Jian Xiao,Hao
Wen,Liang
Wang,Lubin
Xu,Zhihui
Hao,Chang-Lun
Shao,Chang-Yun
Wang,Catalyst-free
dehydrative SN1-type reaction of indolyl alcohols with
diverse nucleophiles “on water”, Green Chemistry, 2015, 18(4):
1032~1037
(10) Jian Liu,Liang
Wang,Xiaoxiao
Wang,Lubin
Xu,Zhihui
Hao,Jian
Xiao, Fluorinated alcohol-mediated [4 + 3] cycloaddition reaction of
indolyl alcohols with cyclopentadiene,Org.
Biomol. Chem.,
2016, 14(48): 11510~11517
(11) Shiheng Fu,Liang
Wang,Haoxun
Dong,Junqiang
Yu,Lubin
Xu,Jian
Xiao,Facile
synthesis of 2-alkenylazaarenes via dehydrative coupling of
2-methylazaarenes with aldehydes ‘on water’,
Tetrahedron Lett., 2016,
57(41): 4533~4536
(12) Xianhui Zhang,Shuai-Shuai
Li,Liang
Wang,Lubin
Xu,Jian
Xiao,Zhen-Jiang
Liu,2-Methylquinoline
promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO:
facile synthesis of α-amino aryl ketones,Tetrahedron,
2016, 72(49): 8073~8077
(13) Haoxun Dong,Lubin
Xu,Shuai-Shuai
Li,Liang
Wang,Chang-Lun
Shao,Jian
Xiao,Facile
Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High
Biological Activities via Three-Component C(sp(3))-H
Functionalization, ACS Combinatorial Science, 2016, 18(9): 604~610
(14) Xianhui Zhang, Shuai-Shuai Li, Liang Wang, Lubin Xu, Jian
Xiao*, 2-Methylquinoline promoted oxidative ring-opening of
N-sulfonyl aziridines with DMSO: facile synthesis of a-amino aryl
ketones, Tetrahedron 2016,
72(49): 8073-8077.
(15) Shuai-Shuai Li, Shiheng
Fu, Liang Wang, Lubin Xu, and Jian Xiao,
t‑BuOK-Mediated Oxidative
Dehydrogenative C(sp3)‑H Arylation of 2‑Alkylazaarenes with
Nitroarenes, J. Org. Chem.
2017, 82(16): 8703−8709
(15) Shuai-Shuai Li, Lan Zhou,
Liang Wang, Huaili Zhao,
Liping Yu, and Jian Xiao, Organocatalytic C(sp3)−H Functionalization
via Carbocation-Initiated Cascade [1,5]-Hydride
Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]-azepines,
Org. Lett. 2018, 20(1):
138−141
(16) Shuai-Shuai Li, Lan Zhou,
Liang Wang, Huaili Zhao,
Liping Yu, and Jian Xiao*, Organocatalytic C(sp3)−H
Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride
Transfer/Cyclization: Synthesis of Dihydrodibenzo- [b,e]azepines,
Org. Lett. 2018, 20,
138−141.
(17) Wei Cao, Ping Chen,
Liang Wang, Hao Wen, Yu Liu, Wanshu Wang and Yu Tang*, A Highly
Regio- and Stereoselective Syntheses of α‑Halo Enamides, Vinyl
Thioethers, and Vinyl Ethers with Aqueous Hydrogen Halide in
Two-Phase Systems, Org. Lett.
2018, 20, 4507−4511.
(18) Yujian Mao, Ye Liu, Yanwei Hu,
Liang Wang, Shilei Zhang*
and Wei Wang*, Pd-Catalyzed Debenzylation and Deallylation of Ethers
and Esters with Sodium Hydride,
ACS Catal. 2018, 8,
3016−3020.
(19) Hao Wen, Wei Cao, Yu Liu,
Liang Wang, Ping Chen*,
Yu Tang*, Metal-Free [2 + 2 + 2] Cycloaddition of Ynamide−Nitriles
with Ynamides: A Highly Regio- and Chemoselective Synthesis of
δ‑Carboline Derivatives, J.
Org. Chem. 2018, 83, 13308−13324.
(20) Yao-Bin Shen, Shuai-Shuai Li,
Liang Wang, Xiao-De An,
Qing Liu, Xicheng Liu, and Jian Xiao, Organocatalytic Dearomative [4
+ 2] Cycloadditions of Biomass-Derived 2,5-Dimethylfuran with
ortho-Quinone Methides: Access to Multisubstituted Chromanes,
Org. Lett. 2018, 20, 6069−6073.