李帅帅，博士，教授，博士研究生导师，山东省农用药物绿色创制与应用特色实验室主任，青岛市农业循环经济材料工程研究中心副主任，山东省高等学校优秀青年科技创新团队天然产物及药物仿生合成与应用创新团队带头人，入选首批山东省青年科技托举人才工程，致力于药物、药物中间体等精细化学品的绿色精准合成。主持国家自然科学基金面上项目、国家自然科学基金青年基金、山东省重点研发计划、山东省自然科学基金等11项课题；以第一或通讯作者身份在ACS Catalysis, Chemical Science, Green Chemistry, Organic Letters等国际著名SCI期刊发表论文48篇，其中中科院Top一区论文26篇，ESI前1%高被引论文3篇；申请PCT国际专利1件；授权发明专利4件，实现技术转让1项；授权PCT国际专利1件；获山东化学化工学会优秀科技工作者称号；兼任山东省科技特派员、山东罗欣药业集团股份有限公司特聘研究员等；指导研究生获山东省优秀毕业生等荣誉。

人才称号：

2018年，入选首批山东省青年科技托举人才工程(共20人)。

2019年，入选山东省高等学校优秀青年科技创新团队(2019KJM002)，并担任天然产物及药物仿生合成与应用创新团队带头人。

社会兼职：

山东罗欣药业集团股份有限公司，特聘研究员

青岛瀚生生物科技股份有限公司，在职博士后

山东省科技特派员

研究方向：

基于过渡金属及有机小分子催化的串联去芳香化反应；研究绿色、温和条件下多步串联反应构建具有生物活性的有机分子，药物及其中间体。

教育经历：

2016.11-至今    必威， 教授

2011.9~2016.7   中科院成都有机所(硕博连读)，博士，师从张晓梅研究员和董琳教授

2007.9~2011.7   临沂大学化学化工学院，     学士，师从彭安顺教授

主持代表性科研项目：

1. 融合sp3碳氢键官能化过程的去芳香化反应构建手性稠杂环化合物(21978144)，国家自然科学基金面上项目, 主持，2020/01-2023/12，65 万元；

2. 神经类药物米安色林及其类似物的高效合成新方法(2019GSF108020)，山东省重点研发计划，主持，2019/01-2020/12，15 万元；

3. “经略海洋”战略背景下的药物创制研究(2019RKB01027)，山东省重点研发计划，主持，2019/12-2021/10，10 万元；

4. 海洋天然产物及药物仿生合成与应用(2019KJM002)，山东省高等学校优秀青年科技创新团队，带头人，2019/03-2022/03，20 万元；

5. 基于氢迁移策略的七元环构建新方法(21702117)，国家自然科学基金青年基金, 主持，2018/01-2020/12，27.6 万元；

6. 新型氢迁移/环化串联反应构建中环化合物研究(ZR2017BB005)，山东省自然科学基金博士基金，主持，2017/8-2019/12，8 万元；

7. 山东省青年科技托举人才工程，2018/10-2021/10，15 万元；

8. 山东省博士后创新资助项目，2021/10-2022/10，3 万元；

9. betway必威西汉姆联官网高层次人才启动基金(6651118009)，2018/12-2023/12，主持，100 万元；

10. 青岛科技大学化学学部开放基金(QUSTHX202004)，2019/11-2020/11，主持，3万元；

11. 3,4-二氢-3-(2-羟基苯甲酰)-2(1H)-喹啉酮类生物活性分子的开发与利用(6602421167)，主持，技术转化，2021/10-2024/10，5万元。

企业牵头，作为技术负责人获批项目：

12. 低酸值高磷脂含量南极磷虾油的研发与产业化(2023TSGC0779)，山东省科技型中小企业创新能力提升工程，技术负责人，2023/07-2025/07，40万。

13. 连续流制备丙硫菌唑关键技术攻关及产业化示范，青岛市关键技术攻关及产业化示范类项目，高校技术负责人，2024/01-2025/12，300万。

获奖情况：

国家级老员工创新训练指导教师，2020年（A类结题），2021年（A类结题）

山东省老员工创新训练指导教师，2022年，2023年

betway必威西汉姆联官网优秀学士论文指导教师，2019年，2020年

长和国际奖教金，2020年

betway必威西汉姆联官网优秀班主任，2019年

betway必威西汉姆联官网先进个人，2018年，2019年，2021年，2023年

优秀党员，2021年

山东化学化工学会科学技术奖，2022年

最美教师，2022年

中国博士后创新创业大赛优胜奖，2022年

山东化学化工学会优秀科技工作者，2023年

教学情况：

主讲《高等有机化学》、《有机化学B》、《有机化学C》、《应用化学前沿》、《基础化学实验》等课程。

代表性成果列表（第一或通讯作者）：

48. Ying Dong,§ Fangzhi Hu,§ Huixin Wu, Feng-Wei Guo, Liang Wang, Feng-Yu Du,* Shuai-Shuai Li*, Controllable Synthesis of N-Heterocycles via Hydride Trans-fer Strategy-enabled Formal [5+1] and [5+2] Cyclizations, Org. Lett. 2024, 1, 332–337 (IF = 5.2, 中科院top一区)

47. Zhipeng Sun,§ Ranran Hou,§ Shuai-Shuai Li,* Xinyu Wang, Liang Wang, Fangzhi Hu,* Feng-Wei Guo*, Controllable Synthesis of N-Containing and O-Containing Heterocycles via Formal [3+2] and [5+2] Cyclizations, Org. Lett. 2024, 1, 6–11. (IF = 5.2, 中科院top一区)

46. Fangzhi Hu, Zhipeng Sun, Mengzhe Pan, Liang Wang, Lubin Xu, Xiong-Li Liu, Shuai-Shuai Li*, Divergent synthesis of nitrogen heterocycles via H2O-mediated hydride transfer reactions, Green Chem. 2023, 25, 5134–5141. (IF = 9.8, 中科院top一区)

45. Lianyi Cao, Fangzhi Hu, Jiacheng Dong, Xiao-Mei Zhang,* Shuai-Shuai Li*, Aromatization-driven cascade [1,5]-hydride transfer/cyclization for synthesis of spirochromanes, Org. Chem. Front. 2023, 10, 1796-1802. (IF = 5.456, 中科院top一区)

44. Yufeng Wang, Qiang Li, Xiaopei Song, Jing Wang, Xiangcong Yin, Shuai-Shuai Li*, Liang Wang*, Chemoselective and diastereoselective construction of 4-alkylidene-tetrahydroquinoline via a redox-neutral vinylogous cascade [1,7]-hydride transfer/6-endo-trig cyclization strategy, Org. Biomol. Chem. 2023, 21, 4007–4012. (IF = 3.89, 中科院三区)

43. 陈玉琢†, 孙红梅†, 王 亮, 胡方芝*, 李帅帅*, 基于 α-氢迁移策略构建杂环骨架的研究进展, 有机化学, 2023, 43, 2323～2337. Invited Review

42. Yao-Bin Shen, Fangzhi Hu, Shuai-Shuai Li*, Alkyl amines and ethers as traceless hydride donors in [1,5]-hydride transfer cascade reactions, Org. Biomol. Chem. 2023, 21, 700-714. Invited Review (IF = 3.89, 中科院三区)

41. Fangzhi Hu, Liang Wang, Peng Wang, Zhanshuai Ding, Yuzhuo Chen, LubinXu, Xiong-Li Liu, Shuai-Shuai Li*, Switchable construction of oxa-heterocycles with diverse ring sizes via chemoselective cyclization controlled by dibrominated compounds, Org. Chem. Front. 2022, 9, 6187-6193. (IF = 5.456, 中科院top一区)

40. Yao-Bin Shen,† Fangzhi Hu,† Shuai-Shuai Li*, Advances in α-C(sp3)–H functionalization of ethers via cascade [1,n]-hydride transfer/cyclization, Tetrahedron 2022, 127, 133089. Invited Review (IF = 2.388, 中科院三区)

39. Fangzhi Hu,† Yao-Bin Shen,† Liang Wang, Shuai-Shuai Li*, Merging dearomatization with redox-neutral C(sp3)–H functionalization via hydride transfer/cyclization: recent advances and perspectives, Org. Chem. Front. 2022, 9, 5041-5052. Invited Review (IF = 5.456, 中科院top一区)

38. Ronghao Xie,‡ Shixiao Chen,‡ Yufeng Wang, Xiangcong Yin, Shuai-Shuai Li*, Lubin Xu and Liang Wang*, Controllable construction of pharmaceutically significant scaffolds of 2,3-dihydroquinolin-4-one and benzoazepine-5-one via redox-neutral cascade hydride transfer/cyclization, Org. Chem. Front. 2022, 9, 5205-5212. (IF = 5.456, 中科院top一区)

37. Chunyan Ge, Liang Wang, Fangzhi Hu, Zhanshuai Ding, Xinyao Li, Deshuai Xiao, Jiayi Wang, Shuai-Shuai Li*, HFIP-mediated imidization of electron-rich arenes with in situ formed spiroindolenines as new imidization reagents for facile construction of 2-arylspiroindolenines, Org. Chem. Front. 2022, 9, 1696-1702. (IF = 5.456, 中科院top一区)

36. Lianyi Cao, Fangzhi Hu, Hongmei Sun, Xiaomei Zhang,* Shuai-Shuai Li*, Redox-triggered dearomative [5+1] annulation of indoles with O-alkyl ortho-oxybenzaldehydes for synthesis of spirochromanes, Org. Chem. Front. 2022, 9, 1668-1674. (IF = 5.456, 中科院top一区)

35. Fangzhi Hu, Xinyao Li, Zhanshuai Ding, Liang Wang, Chunyan Ge, Lubin Xu, and Shuai-Shuai Li*, Divergent Synthesis of [3,4]-Fused 3‑Alkenyl-Oxindoles via Propargyl Alcohol-Triggered C(sp3)−H Functionalization, ACS Catal. 2022, 12, 943-952. (IF = 13.70, 中科院top一区)

34. Ronghao Xie, Shixiao Chen, Xianping Xiang, Xiangcong Yin, Lubin Xu, Shuai-Shuai Li,* Liang Wang* and Fengying Dong*, Diastereoselective construction of structurally diverse 2,3-dihydroquinolin-4-one scaffolds via redox neutral cascade [1,7]-hydride transfer/cyclization, Org. Chem. Front. 2022, 9, 660–666. (IF = 5.456, 中科院top一区)

33. Fangzhi Hu, Liang Wang, Chunyan Ge, Xinyao Li, Zhanshuai Ding, Lubin Xu, Shuai-Shuai Li*，Divergent α-Functionalization of Cyclic Amines via Ring Construction by Molecular O2 Oxidized Dearomatization and Ring Deconstruction by Aromatization Driven C-C σ-Bond Cleavage, Green Chem. 2021, 23, 5535–5541 (IF = 11.034, 中科院top一区)

32. Mengzhu Guo, Fengying Dong, Xiangcong Yin, Lubin Xu, Liang Wang*, and Shuai-Shuai Li*, Facile Syntheses of Tetrahydroquinolines and 1,2-Dihydroquinolines via Vinylogous Cascade Hydride Transfer/Cyclization, Org. Chem. Front. 2021, 8, 2224–2231. (IF = 5.456, 中科院top一区)

31. Xiaoyu Yang, Jianlin Liu, Fangzhi Hu, Hongmei Sun, Liang Wang*, and Shuai-Shuai Li*, Diverse Application of 4-Hydroxycoumarin in Syntheses of Tetrahydroquinoline and Zwitterionic Biscoumarin Derivatives, Chin. J. Org. Chem., 2021, 41, 2788-2799. (中国期刊 《有机化学》，中科院三区)

30. Xiaoyu Yang, Liang Wang, Fangzhi Hu, Lubin Xu, Sanming Li, and Shuai-Shuai Li*, Redox-Triggered Switchable Synthesis of 3,4-Dihydroquinolin-2(1H)-one Derivatives via Hydride Transfer/N-Dealkylation/N-Acylation, Org. Lett. 2021, 23, 358–364. (IF = 6.005, 中科院top一区)

29. Kejin Yuan, Fengying Dong, Xiangcong Yin, Shuai-Shuai Li*, Liang Wang,* Lubin Xu*, The dual alkylation of the C(sp3)-H bond of the cyclic α-methyl-N-sulfonyl imines via sequential condensation/hydride transfer/cyclization process, Org. Chem. Front. 2020, 7, 3868–3873. (IF = 5.456, 中科院top一区)

28. Yingying Xing, Fengying Dong, Xiangcong Yin, Liang Wang* and Shuai-Shuai Li*, Facile Construction of 3,4-dihydro-2H-1,2,4-Benzothiadiazine 1,1-Dioxides via Redox-Neutral Cascade Condensation/[1,7]-Hydride Transfer/Cyclization, Asian J. Org. Chem. 2020, 9, 1787-1792. (IF = 3.319, 中科院三区)

27. Kang Duan, Hongjin Shi, Lin-Xuan Wang, Shuai-Shuai Li*, Lubin Xu, Jian Xiao*, Hydride Transfer Enabled Switchable Dearomatization of Indoles in the Carbocyclic Ring and the Pyrrole Ring, Org. Chem. Front. 2020, 7, 2511–2517. (IF = 5.456, 中科院top一区)

26. Fangzhi Hu, Liang Wang, Lubin Xu and Shuai-Shuai Li*, Aromatization-driven Deconstruction/refunctionalization of Unstrained Rings, Org. Chem. Front. 2020, 7, 1570–1575. (IF = 5.456, 中科院top一区)

25. Xiaoyu Yang, Fangzhi Hu, Liang Wang, Lubin Xu and Shuai-Shuai Li*, Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer, Org. Biomol. Chem. 2020, 18, 4267–4271. (IF = 3.876, 中科院三区)

24.  Hongjin Shi, Liang Wang, Shuai-Shuai Li*, Yongjun Liu, and Lubin Xu*, Divergent syntheses of spirooxindoles from oxindole-embedded four-membered synthon via cycloaddition reactions, Org. Chem. Front. 2020, 7, 747–755. (IF = 5.456, 中科院top一区)

23. Hongjin Shi, Lubin Xu, Didi Ren, Liang Wang,* Weisi Guo and Shuai-Shuai Li*, Fluorinated alcohol mediated N,N’-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline, Org. Biomol. Chem. 2020, 18, 895-904. (IF = 3.876, 中科院三区)

22.  Lan Zhou, Yao-Bin Shen, Xiao-De An, Xian-Jiang Li, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Redox-Neutral β‑C(sp3)−H Functionalization of Cyclic Amines via Intermolecular Hydride Transfer, Org. Lett. 2019, 21, 8543−8547. (IF = 6.005, 中科院top一区)

21.  Guangxian Bai, Fengying Dong, Lubin Xu, Yongjun Liu, Liang Wang,* and Shuai-Shuai Li*, Controllable Syntheses of Spiroindolenines and Benzazepinoindoles via Hexafluoroisopropanol-Mediated Redox-Neutral Cascade Process, Org. Lett. 2019, 21, 6225-6230. (IF = 6.005, 中科院top一区)

20.  Shuai-Shuai Li, Shuai Zhu, Chunqi Chen, Kang Duan, Qing Liu, and Jian Xiao*, Redox-Neutral Cascade Cyclizations for Construction of Spirocyclic Bisoxindoles Featuring a [3,4]-Fused Oxindole Moiety, Org. Lett. 2019, 21, 1058-1062. (IF = 6.005, 中科院top一区)

19.  Didi Ren, Lubin Xu, Liang Wang*, Shuai-Shuai Li*, Catalytic Formal Benzylic C−H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents, Org. Lett. 2019, 21, 627–631. (IF = 6.005, 中科院top一区)

18.  Shuai Zhu, Chunqi Chen, Kang Duan, Yun-Ming Sun, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Cascade [1,5]-Hydride Transfer/Cyclization for Synthesis of [3,4]-Fused Oxindoles, J. Org. Chem. 2019, 84, 8440−8448. (IF = 4.354, 中科院二区)

17. Xintong Lv,# Fangzhi Hu,# Kang Duan, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Aromatization-Driven Cascade [1,5]-Hydride Transfer/Spirocyclization Promoted by Fluorinated Alcohols, J. Org. Chem. 2019, 84, 1833-1844. (IF = 4.354, 中科院二区, 高被引论文)

16. Shuai-Shuai Li, Xintong Lv, Didi Ren, Chang-Lun Shao, Qing Liu and Jian Xiao*, Redox-Triggered Cascade Dearomative Cyclizations Enabled by Hexafluoroisopropanol, Chem. Sci. 2018, 9, 8253–8259. (IF = 9.825, 中科院top一区)

15. Shuai-Shuai Li,# Lan Zhou,# Liang Wang, Huaili Zhao, Liping Yu, and Jian Xiao*, Organocatalytic C(sp3)-H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines, Org. Lett. 2018, 20, 138-141. (IF = 6.005, 中科院top一区)

14.  Chunqi Chen, Lubin Xu, Liang Wang* and Shuai-Shuai Li*, Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization, Org. Biomol. Chem. 2018, 16, 7109–7114. (IF = 3.876, 中科院三区)

13. Shuai-Shuai Li, Shiheng Fu, Liang Wang, Lubin Xu, and Jian Xiao, t-BuOK-Mediated Oxidative Dehydrogenative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes, J. Org. Chem. 2017, 82, 8703. (IF = 4.354, 中科院二区)

12. Shuai-Shuai Li, Lin Wu, Liu Qin, Yu-Qin Zhu, Fu Su, Yan-Jun Xu*, Lin Dong*, Iridium(III)-catalyzed Tandem [3 + 2] Annulation: Synthesis of Spirocyclic Phosphoramide Derivatives, Org. Lett. 2016, 18, 4214-4217. (IF = 6.555, 中科院top一区)

11. Shuai-Shuai Li, Cheng-Qi Wang, Hui Lin, Xiao-Mei Zhang, Lin Dong*, Rhodium(III)-Catalyzed Oxidative Annulation of 7‑Azaindoles and Alkynes via Double C-H Activation, Org. Lett. 2015, 17, 3018-3021. (IF = 6.555, 中科院top一区)

10.  Shuai-Shuai Li, Hui Lin, Chen-Fei Liu, Ying-Qi Xia, Xiao-Mei Zhang, Lin Dong*, Rhodium-Catalyzed Tandem Annulation Reactions of 7-Azaindoles with Electron-Deficient Olefins via Double C-H Activation, Adv. Synth. Catal. 2016, 358, 1595-1601.

9.  Shuai-Shuai Li#, Ying-Qi Xia#, Chen-Fei Liu, Guo-Tai Zhang, Xiao-Mei Zhang, Lin Dong*, Diverse Reactivity in a Rhodium(III)-Catalyzed Vinylic sp2 C–H Bond Functionalization: Synthesis of Fused Polycyclic Heteroarenes or Conjugated Dienes, Adv. Synth. Catal. 2016, 358, 3724-3729.

8.  Shuai-Shuai Li#, Chen-Fei Liu#, Guo-Tai Zhang, Ying-Qi Xia, Wei-Huan Li, Lin Dong*, A Convenient One-Pot Route to Screw-Shaped [5]Azahelicenes via Rhodium(III)-Catalyzed Multiple C−H Bond Activation, Chemistry – An Asian Journal 2017, 12, 415-418.

7.   Shuai-Shuai Li, Ying-Qi Xia, Fang-Zhi Hu, Chen-Fei Liu, Xiao-Mei Zhang, Lin Dong*, IrIII-Catalyzed One-Pot Cascade Synthesis of Pentacyclic-Fused Carbazoles from Indoles and Diazoes, Chemistry – An Asian Journal 2016, 11, 3165-3168.

6.  Shuai-Shuai Li, Cheng-Qi Wang, Hui Lin, Xiao-Mei Zhang, Lin Dong*, Rhodium(III)-catalyzed C–C coupling of 7-azaindoles with vinyl acetates and allyl acetates, Org. Biomol. Chem. 2016, 14, 229-237.

5.  Shuai-Shuai Li#, Liu Qin#, Lin Dong*, Rhodium-catalyzed C–C Coupling Reactions via Double C–H Activation, Org. Biomol. Chem. 2016, 14, 4554-4570. (过渡金属铑催化双C-H活化综述，高被引论文)

4.  Shuai-Shuai Li, Chen-Fei Liu, Ying-Qi Xia, Xiao-Mei Zhang, Lin Dong*, A Unique Annulation of 7-Azaindoles with Alkenyl Esters to Produce π-Conjugated 7-Azaindole Derivatives, Org. Biomol. Chem. 2016, 14, 5214-5218.

3.  Shuai-Shuai Li#, Wei-Huan Li#, Guo-Tai Zhang, Ying-Qi Xia, Xiao-Mei Zhang, Lin Dong*, One-pot Construction of Fused Polycyclic Heteroarenes Involving 7-Azaindoles and α,β-Unsaturated Ketones, Org. Biomol. Chem. 2016, 14, 7859-7863.

2.  Shuai-Shuai Li, Hui Lin, Xiao-Mei Zhang, Lin Dong*, Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones, Org. Biomol. Chem. 2015, 13, 1254-1263.

1.  Shuai-Shuai Li, Cheng-Qi Wang, Wei-Huan Li, Xiao-Mei Zhang, Lin Dong*, Rhodium-catalyzed Selective Oxidative Coupling of 7-Azaindoles, Tetrahedron 2016, 72, 2581-2586.

授权专利：

1. 3,4-二氢-3-(2-羟基苯甲酰)-2(1H)-喹啉酮活性骨架及合成方法和应用

（专利号：ZL 201910530179.4）

发明人：李帅帅、胡方芝、王亮、徐鲁斌、杨晓宇

2. 一种氧气促进的去芳香化反应在构建螺环二烯酮骨架中的应用

(专利号：ZL 202110792351.0)

发明人：李帅帅、胡方芝、李鑫瑶

3. 一种双香豆素内盐生物活性骨架的绿色合成方法及应用

(专利号：ZL 202110224263.0)

发明人：李帅帅、胡方芝、王亮、徐鲁斌、杨晓宇

联系方式：18661797516；邮箱：flyshuaishuai@126.com